IRIS: A concern for people
starting HIV therapy

April 2008     View PDF     En español

Commentary

If another infection besides HIV is present before starting therapy, IRIS is more likely to develop. As well, the greater the drop in HIV levels (2.5 logs or more) and the fewer CD4s before starting therapy (below 50), the more likely it will occur. However, IRIS has also been seen in people with somewhat higher CD4s (below 100) and less dramatic drops in HIV levels (1.0 logs or more).

Much has been learned about IRIS, though a good deal more still needs to be understood. Current research is answering more of these questions, especially ways to test for whom is more likely to develop IRIS and more specific answers for knowing when it may happen. It’s wise for those who face first line therapy to understand your risks, especially if your immune system is severely damaged. Reporting your symptoms can help inform your doctor of a situation that may need to be more closely managed and treated.