Systemic candidiasis

January 2005     View PDF     En español

Drug interactions

There are no known drug interactions for any topical treatment. The oral azole drugs have similar drug interactions.

• Anyone taking the antihistamines terfenadine (Seldane) or astemizole (Hismanal) or the anti-reflux drug cisapride (Propulsid) SHOULD NOT take ketoconazole or itraconazole and should probably avoid fluconazole. These drugs can interact to give serious heart problems.
• Azole drugs should not be taken with the sedatives triazolam (Halcion) or midazolam (Versed) as this could lead to dangerous levels of sedation.
• When taken with the blood-thinning agent warfarin, azole drugs can make the blood clot more slowly, so clotting time should be monitored.
• Taking azoles with oral hypoglycemic drugs may result in severe hypoglycemia, so blood sugar (glucose) levels should be checked carefully.
• Other drug interactions may occur. More details can be found in Drug Interactions and from your pharmacist.