Category Archives: HIV care & treatment

CROI2015: New “Kick and Kill” HIV cure drug (TLR7 agonist) from Gilead shows promise

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A new type of drug, called a toll-like receptor 7 (TLR7) agonist, was able to activate HIV-infected CD4 cells from HIV-positive donors on antiretroviral therapy (ART), leading to the release and replication of virus, according to a presentation at the 2015 Conference on Retroviruses and Opportunistic…Read More

CROI2015: Financial incentives don’t increase case linkage or viral suppression

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A large study presented at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle found that offering gift cards to people to reward them for getting into HIV care after testing positive or for getting their viral loads suppressed doesn’t work better than the…Read More

CROI2015: The risk for transmission persists through the first six months of HIV treatment

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At the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, an analysis from the Partners PrEP Study revealed that the risk for HIV transmission within the first six months of starting HIV treatment is still possible before full suppression is attained. Although HIV levels…Read More

CROI2015: Using raltegravir or protease inhibitors influences about equal levels of fat gains

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At the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, the ACTG 5260s study showed increases in body fat after starting a regimen with either raltegravir, boosted darunavir (Prezista) or boosted atazanavir (Reyataz) — with no differences seen between those regimens. Earlier study has…Read More

CROI2015: New HIV maturation inhibitor BMS-955176 appears more potent than earlier beviramat

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At the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, results were presented from a phase 2a study of the new maturation inhibitor, BMS-955176. This “second-generation” drug inhibits HIV in the last steps of its life cycle by preventing it from becoming fully mature…Read More

CROI2015: Promising results for new HIV attachment inhibitor drug fostemsavir (BMS-663068) as it moves through study

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At the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, 48-week results were presented from a phase 2b study of the new attachment inhibitor fostemsavir (BMS-663068). This drug is unique as it targets the surface protein gp120 on the virus which prevents attachment to…Read More

CROI2015: Dutch ATHENA study announces surprising results when using 3TC (lamivudine) over FTC (emtricitabine)

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At the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, the Dutch ATHENA cohort of HIV-positive people reported that those taking a regimen with 3TC had a higher risk of treatment failure than those taking FTC. However, these results come with some caveats, as…Read More